Professor Andrew David Smith

University of St Andrews
School of Chemistry
Purdie Building
North Haugh
St Andrews
KY16 9ST
United Kingdom

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We are an organic synthesis and catalysis focused research group, with particular interests in the fields of asymmetric organocatalysis and synthetic methodology development.

Synthetic organic chemistry and catalysis has applications that span the breadth of contemporary science, ranging from materials chemistry to chemical biology. Within this remit, our research focuses upon the development of novel (asymmetric) processes using organocatalytic methods, while advancing a mechanistic understanding of these transformations. In all projects we aim to discover novel approaches to the assembly of functional molecules, with progress outlined below and referenced to our publications.


Organocatalytic Michael addition–lactonisation...........

Full title: Organocatalytic Michael addition–lactonisation of carboxylic acids using α,β-unsaturated trichloromethyl ketones as α,β-unsaturated ester equivalents

L. C. Morrill, D. G. Stark, J. E. Taylor, S. R. Smith, J. A. Squires, A. C. A. D'Hollander, C. Simal, P. Shapland, T. J. C. O'Riordan and A. D. Smith

DOI: 10.1039/C4OB01788A

Asymmetric Synthesis of Tri- and Tetrasubstituted .....

Full title: Asymmetric Synthesis of Tri- and Tetrasubstituted Trifluoromethyl Dihydropyranones from α-Aroyloxyaldehydes via NHC-Redox Catalysis

A. T. Davies, P. M. Pickett, A. M. Z. Slawin and A. D. Smith

ACS Catal., 2014, 4, 2696-2700

Stereodivergent Organocatalytic Intramolecular Michael.........

Full title: Stereodivergent Organocatalytic Intramolecular Michael Addition/Lactonization for the Asymmetric Synthesis of Substituted Dihydrobenzofurans and Tetrahydrofurans

D. Belmessieri, A. de la Houpliere, E. D. D. Calder, J. E. Taylor and A. D. Smith

Chem. Eur. J., 2014, 20, 9762-9769


Contact details:


Direct phone: +44 (0)1334 463896

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