The University of Groningen in the Netherlands

ITN Post-doc position

Biocatalysis

Starting date: ca. August-November 2015

Biotransformation and Biocatalysis, Groningen Biomolecular Sciences and
Biotechnology Institute and Stratingh Institute,
University of Groningen
Nijenborgh 4, 9747 AG Groningen, the Netherlands

Description

The one-year position is part of the Marie Curie Initial Research Training Network SUBICAT (www.subicat.org), aimed at the design of chemical and enzymatic conversions that lead to the production of useful chemicals from biomass. The project is a collaboration between organic chemistry and biochemistry and is aimed at the discovery, production and use of enzymes for functionalization of aromatics derived from lignin, such as cinnamic acid and coumaric acid analogs. The target conversions are incorporation of nitrogen groups, e.g. by aminotransferase and ammonia lyase reactions. The approach will be to select enzymes by genome mining and bioinformatic analysis, isolate them, and explore their activity in desired reactions. Substrate scope and catalytic performance will be explored. In collaboration with other group members, homology modeling and docking simulations will be used to rationalize results. The collaboration with organic chemistry involves mainly product analysis and reaction optimization. It is expected that the successful applicant will also spend some time in one of the labs of the industrial or academic partners.

Important qualifications

  • Applicants must hold an PhD degree, or comparable, in (bio)chemistry, organic chemistry, molecular biology, applied biocatalysis, or similar
  • Experience with molecular biology, enzyme isolation and characterization, biocatalytic conversions, and relevant analytical methods.
  • Please note that for this position the Marie-Curie mobility criterion applies. This means that the applicant cannot have spent more than 12 months in the country where he/she will be recruited (The Netherlands) in the last 3 years. In addition the day on which the Ph.D. was obtained should be less than 5 years ago on the moment the contract starts.

Personal traits

  • Organized, reliable, careful and ambitious worker
  • Independence and perseverance
  • Team worker, open to collaboration with other researchers
  • Good oral and written command of English.

Further information
Prof. Dick B. Janssen, phone +31-50-3634008; e-mail d.b.janssen@rug.nl.
Prof. J. (Hans) G. de Vries, e-mail johannes.devries@catalysis.de.